Re: On Drug Use
Thanks Tal and aperson, I didn't know the difference, but there's definitely one there. I think that the term physical dependence would be better than physical addiction, but whatever's standard.
I don't know much about where cocaine starts to work specifically, however, I did write a mediocre paper around a year ago which discusses the role of the prefrontal cortex and nucleus accumbens in regulating drug-seeking behaviour. The release of dopamine in the ventral tegmental area or the basolateral amygdala isn't the end of the line, so to speak, in terms of reward/behaviour seeking system. The dopamine projections involved in drug-seeking behaviour in rats activate the dorsal prefrontal cortex, which then activate the nucleus accumbens, and then the ventral pallidum. The studies I found indicated the glutamatergic activation in the PFC and NA are what's really at the heart of some drug-seeking behaviour.
Well, it's alright to be informed about being in the correct state of mind in order to use drugs, but I think that no matter how much I read about how to have a good trip, I still think I'm going to be ignorant about what a drug's really like until I experience it myself. If what you say is largely true, that my trip would depend on my state of mind that I can control, I think I'd better stay away from hallucinogens, because my state of mind is fickle and often not very healthy, and I have a hard time staying in control enough as it is.
I get more about you're saying about the person being the cause of drug problems, but for highly addictive drugs, once a person's addicted, its just downhill from there, and it's pretty harsh to put all the blame on the person. People demonize all drugs because it's easier than saying some are good for reasons a and b, but bad for reason c, and there's the hope that if all of them are put down, then it will stop those people who won't ever bother informing themselves properly from ever trying any.
Thanks Tal and aperson, I didn't know the difference, but there's definitely one there. I think that the term physical dependence would be better than physical addiction, but whatever's standard.
I don't know much about where cocaine starts to work specifically, however, I did write a mediocre paper around a year ago which discusses the role of the prefrontal cortex and nucleus accumbens in regulating drug-seeking behaviour. The release of dopamine in the ventral tegmental area or the basolateral amygdala isn't the end of the line, so to speak, in terms of reward/behaviour seeking system. The dopamine projections involved in drug-seeking behaviour in rats activate the dorsal prefrontal cortex, which then activate the nucleus accumbens, and then the ventral pallidum. The studies I found indicated the glutamatergic activation in the PFC and NA are what's really at the heart of some drug-seeking behaviour.
Well, it's alright to be informed about being in the correct state of mind in order to use drugs, but I think that no matter how much I read about how to have a good trip, I still think I'm going to be ignorant about what a drug's really like until I experience it myself. If what you say is largely true, that my trip would depend on my state of mind that I can control, I think I'd better stay away from hallucinogens, because my state of mind is fickle and often not very healthy, and I have a hard time staying in control enough as it is.
I get more about you're saying about the person being the cause of drug problems, but for highly addictive drugs, once a person's addicted, its just downhill from there, and it's pretty harsh to put all the blame on the person. People demonize all drugs because it's easier than saying some are good for reasons a and b, but bad for reason c, and there's the hope that if all of them are put down, then it will stop those people who won't ever bother informing themselves properly from ever trying any.



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